Profacgen, a protein service provider that enabling access to the latest tools, techniques, and expertise, recently enhanced its CLIP-Seq service which can map the RNA-binding landscape of interacting proteins or RNA modification sites over a genome-wide scale.

 

CLIP (cross-linking immunoprecipitation) is a technique for studying RNA-protein interactions and locating specific RNA modifications. After UV cross-linking the RNA-protein complex, immunoprecipitation with an antibody against the protein of interest is used. CLIP-Seq, also known as HITS-CLIP, combines CLIP with high-throughput sequencing to identify RBP binding sites. CLIP-Seq can be used to map the RNA-binding landscape of interacting proteins or RNA modification sites across the genome, which aids in the understanding of post-transcriptional regulatory networks and mechanisms.

 

Upon the enhancement, Profacgen’s latest irCLIP-Seq technology utilizes infrared fluorescent dye in place of traditional radioactive materials for labeling. Furthermore, the introduction of the thermostable group II intro reverse transcriptase for cDNA synthesis is intended to empower experimental efficiency and simplify the technical procedure of its customers’ research.

 

Why Choose Profacgen:

  • High Coverage: Screen and identify protein binding sites across the entire transcriptome.
  • Wide Application: RNA-protein interaction mechanism analysis, IncRNA/circRNA functional mechanism analysis, potential miRNA target(s) identification, etc.
  • One-stop Service: Design, develop, optimize and troubleshoot for all stages.
  • Innovative facilities: High-throughput sequencing platforms.

 

“Our extensive experience and capability can assist you in designing, developing, optimizing, and troubleshooting for all stages of your CLIP project with the greatest flexibility and efficiency.” Commented Crystal, the chief marketing staff at Profacgen.

 

Moreover, eCLIP-seq, iCLIP-seq, and RIR-seq are available at Profacgen for studying RNA-protein interactions.

 

Please visit  https://www.profacgen.com/clip-seq-service.htm to know more enhanced CLIP-Seq service provided by Profacgen.

 

 

About Profacgen

Profacgen provides process development and cGMP manufacturing services for biological active ingredients. We have ready access to state-of-the-art biopharmaceutical product development and manufacturing facilities and our staff scientists have demonstrable expertise in all aspects of biopharmaceutical manufacturing, from facility design and operation to the ability to provide best advice relating to product development.